What’s the first thing you reach for when you get a headache? If you’re anything like most people, it’s probably the Advil. Or the Tylenol. Or the generic bottle of ibuprofen — right?
But have you ever really stopped to consider how these drugs work? They provide effective and efficient relief for most headaches, sure, but how safe are they, especially when you suffer from frequent headaches and find yourself taking them on a daily basis?
In this article, we’ll take a long-due look at what’s actually going (physiologically) when headaches creep their way into your life and ruin your otherwise pleasant day. Also, we’ll talk about the dangers of using OTC (over-the-counter) drugs too frequently, and discuss why CBD for headaches is starting to become the treatment of choice for many thousands of headache and migraine sufferers.
Physiology 101: What makes your head hurt?
Truth be told, there isn’t one specific thing that causes a headache. In fact, there are dozens and dozens of different pathways that can produce the physiological effects and cumbersome symptoms of throbbing cranial pain.
Think about it: you can get a headache from stress, tooth pain, from drinking too much (i.e. a hangover), from not drinking enough (i.e. dehydration), from skipping out on your morning coffee, from tumors, from concussions, from getting too much sun, and so on and so forth – there are loads of physiological (and even emotional) reasons why we get headaches.
What’s interesting, though, is the fact that our brains themselves can’t even feel pain. Taking this into consideration, how is it even possible to get a headache? And what is a headache? Where does the pain come from? What is it that’s actually hurting?
As it turns out, doctors believe the physical pain from headaches is the result of inflamed tissue and blood vessels in the cranial region, and/or changes in the release of neurochemicals that stimulate nerves and produce pain signals in the central nervous system.
Headaches can occur on one side of the head (a cluster headache), all over the head, or in one specific, acute location. It’s important to consider that the cranial region is loaded with complex networks of blood vessels, muscles, soft tissues, and pain-sensitive nerves; when inflammation or other irregularities occur in these structures, the resultant condition is often a throbbing headache.
Thus, it’s not your brain that’s hurting during a headache – it’s the network of blood vessels and fragile tissues that surround it.
Conventional headache treatments and dangers of frequent OTC drug use (Advil, Motrin, Aleve, etc)
So taking into consideration the fact that headaches are the result of inflamed tissue or blood vessels in the cranial region, how do conventional OTC (over-the-counter) drugs work to make them go away?
Medications like ibuprofen (which include the brand names Motrin, Advil, and Aleve) are non-steroidal anti-inflammatory drugs (NSAID’s) that have non-addictive analgesic (pain-relieving), anti-pyretic (fever-reducing), and anti-inflammatory effects. These makes them effective options for the onset of headaches, which as we just discussed, are the result of inflamed tissues and blood vessels in the region surrounding the head and neck.
Functionally, the drugs work by blocking the production of prostaglandins, which are inflammation-inducing substances produced by the body that are released as a response to illness or injury. (This is why ibuprofen is also a good fever-reducing OTC medication).
However, in addition to blocking the release of prostaglandins at the site of inflammation, drugs like Advil and Aleve also block/inhibit protective prostaglandins that have a functional role in the stomach and kidneys. This is why it’s very important to always take ibuprofen with food – if you don’t the prostaglandin inhibition will likely result in stomach bleeding.
Also, even if you always take OTC headache medications with food, it’s still dangerous to take them on a daily basis. In addition to their inflammatory roles in the cranial region, prostaglandins are important for dilating blood vessels in the kidneys. Thus, when you take prostaglandin-inhibiting drugs like ibuprofen (especially on a daily basis), you drastically increase the chance of developing chronic kidney conditions such as ischemia, which is the accumulation of dead tissue in the kidney from lack of blood flow.
In addition to NSAID’s, acetaminophen-containing drugs such as Tylenol and Aspirin are also popular and effective headache-relievers. However, when taken on a regular basis, they aren’t much better in terms of dangerous and long-term side effects.
In fact, acetaminophen drugs pose even more of a long-term threat to liver functioning than does ibuprofen; an FDA advisory committee has actually released statements in the past which propose that limits be set on acetaminophen due to their high risk of liver damage when taken frequently.
In short, while headache-relieving OTC drugs are generally safe when taken sporadically, they can cause very real and serious health conditions when relied on on a frequent basis.
Living with frequent headaches/migraines
Anyone who lives with frequent and severe headaches/migraines will tell you that their debilitating-effects are no joke; they’re often times more than enough to keep you home from work or school, or from being productive with whatever it is that you need to get done in your day-to-day life.
Also, the onset of severe headaches can cause a host of other physiological conditions as well, including:
- Severe nausea/vomiting
- Dizziness/blurred vision
- Sensitivity to light and/or noise
- Trouble reasoning, rationalizing, or formulating thoughts
- Pain that increases with activity
CBD for headache relief: How it works
So you’ve likely heard before that CBD for headaches is a “wonder treatment” of sorts. But how true is this, if at all? Is it just another myth drummed up by all the potheads who claim cannabis to be some kind of miracle worker?
Well, instead of relying on opinion or anecdotal evidence to answer this question, we can rely on science and physiology to do the speculating for us (hooray for science!).
In terms of how cannabis works to alleviate headaches, we need to first look at the the basic functioning of the body’s endocannabinoid system.
The endocannabinoid system, or ECS, is a massive network of cannabinoids and cannabinoid receptors that exists naturally in the human body. Everyone has a functional ECS, even if they’ve never taken cannabis or smoked marijuana a day in their lives.
Cannabinoid receptors have been found to exist in virtually every single cell and tissue type in the human body, including the vast network of nerves, muscles, and soft tissues in the cranial region. Functionally, it’s believed that the ECS and its network of cannabinoids and receptors play a crucial role in whole-body homeostasis.
In fact, Dr. Dustin Sulak of the Integr8 Health center in Falmouth, Maine, has gone so far as to call the endocannabinoid system “[perhaps] the most important physiologic system involved in establishing and maintaining human health.”
When you use cannabis (whether it’s smoking flower, taking CBD oil drops, rubbing topicals into your skin, etc) the active cannabinoids in the plant (THC and CBD) will interact with and manipulate natural receptors in the ECS, thereby promoting homeostasis on the whole-body level.
Thus, in the case of headaches (which remember is the result of inflammation in structures of the head and neck), CBD interacts with localized ECS receptors to either A) revert neurochemical release back to appropriate levels, or B) reduce headache-inducing inflammation in acute muscles, tissues, and blood vessel networks.
Studies on CBD for headaches
Fortunately, there has actually been a fair amount of research and published studies on cannabis and the physiological role of CBD for headaches.
First, it’s well-documented that CBD is an effective anti-inflammatory. In a study published in Future Medicinal Chemistry, the effects of active cannabinoids on the ECS were noted to “suppress inflammatory responses” in acute tissue regions, which is exactly what happens in the instance of onset headaches and migraines.
Also, during a presentation at the 3rd Congress of the European Academy of Neurology this past summer (July 2017), one cannabis-based clinical trial showcased active cannabinoids to be more effective than opiate painkillers at reducing chronic migraine pain.
The study, which included 127 participants suffering from frequent migraine, portrayed that CBD-containing medications cut migraine pain among all subjects by approximately 43.5%, compared to 40.1% in the corresponding opiate medication. More importantly, however, was the fact that the cannabis-based medication produced far fewer (essentially zero) side effects.
CBD is becoming incredibly popular for all sorts of medical conditions because unlike THC, it doesn’t get you high. It contains all of the medical benefits of cannabis, with none of the psychoactive effects.
That being said, it’s important to point out that CBD is still a 100% natural cannabinoid that’s found in the marijuana plant – it is NOT synthetically produced. In fact, in most strains of cannabis, it’s usually the second-most abundant compound, behind only THC.
CBD oils are the most potent form of CBD medication, as the carrier oil can contain more active compound by volume than natural flower. Also, CBD is a legal product because it’s produced from the hemp plant — NOT the marijuana plant. Even though they both come from the same species (Cannabis sativa L), hemp is drastically different because by definition it contains less than 0.3% THC. In other words, it’s a type of CBD-rich cannabis that does not produce a psychoactive high.
And lastly, perhaps the biggest draw to CBD-based medications is the fact that they produce almost zero side-effects. We all know the dangers of addiction and overdose that opiate painkillers present, as well as the dangers of liver and kidney complications that are presented by common OTC pain relievers like Aleve and Tylenol. CBD oil, on the other hand, is an all-natural, effective, and incredibly safe medication that has the potential to replace both of these types of synthetic drugs.
The Bottom Line: CBD for headaches
If you do decide to give CBD oil a try for headache relief, however, it’s important to point out that there’s a lot of bogus products currently out there on the market – both online and in vape stores/cannabis dispensaries. Given the early stages of the industry and the lack of consistent federal regulation, a lot of manufacturers have been getting away with packaging, marketing, and selling hemp or “CBD” based products, when in fact they contain very little (or none) of the active compound.
Like we do with all of our medical-based articles, we’ll post some links below to several of the most reputable manufacturers that have been the most consistent and reliable over the past several years.
And of course, always keep in mind that it’s important to do your own research when it comes to selecting the best CBD oil for headaches and migraine relief. While results are positive for the majority of people, not everyone will experience the same improvements in condition.
- Full-spectrum Hemp extract
- No pesticides, solvents or chemical fertilizers
- 3rd party laboratory tested
- Price Range ($48.00 – $139.00)
- Maximum potency and purity
- Compounded by a licensed pharmacist
- Highly concentrated extraction process
- Price Range ($26-$169)
- Full-Spectrum Extract (Made in USA)
- 100% Natural and Organic
- Contain no artificial flavors or preservatives
- Prices range ($48-$125)
- CBDPure uses a chemical-free CO2 extraction process
- 3rd party laboratory tested
- Certified hemp grown in Colorado
- Price Range ($29.99 – $79.99)
- Over 5 Years Experience
- 3rd party laboratory tested
- Organic hemp CO2 extract tincture
- Price Range ($62.00 – $204.00)