Why CBD Oil Won’t Work for Everyone [Answered]

Explaining in detail

Here’s the thing about CBD oil; while it works wonderfully for hundreds of thousands of people, it is NOT a miracle cure. A growing body of CBD research shows its capability in relation to easing the symptoms of conditions such as social anxiety diseases, insomnia, fibromyalgia, cancer, and many others.

However, we believe in CBD oil, NOT snake oil, which is why we know it is not 100% effective for everyone; nothing is. That’s why we get angry when people suggest CBD oil is a scam because it didn’t work for THEM. What you have to realize is that there are good reasons why CBD oil didn’t work for you — and it has nothing to do with its efficacy as a whole. Let’s go into further detail and explore some reasons why CBD isn’t working for you.

Brand & Dosage

Let’s start with the basics: Perhaps you have bought a bad product or else you’re not using enough. Never purchase CBD oil from a company that doesn’t also offer third-party lab results. At present, it is an unregulated industry so a lot of low-standard oil gets through. Third party testing from a reputable lab removes most of the doubt about the reputation of the brand.

In some cases, you’ll get companies that claim their bottles have 1,000mg of CBD but only have 200mg or less. Without lab results, how can you tell? Also, if you are using a quality brand, are you taking enough? And are you using it every day? Generic dosage recommendations are doing the rounds. Here are some examples:

  • 2.5mg a day to increase appetite in cancer patients.
  • 2.5 – 20mg daily to alleviate chronic pain.
  • Up to 400mg a day for epilepsy.

Notice the different doses per condition and the large range? Always begin with a low dose, but keep increasing it until you feel an effect. If you go as far as 100mg a day for pain for instance, and it isn’t working, perhaps CBD is not for you.


Unfortunately, your genetics could be to blame. The reason why CBD oil works is due to the way the body interacts with it. If you have a genetic anxiety disorder for example, you could experience paranoia when using THC but CBD should help you. CBD works with the endocannabinoid system (ECS) and believe it or not, some of us are born with more endocannabinoids than others.

For the record, around 20% of Americans have a genetic mutation that increases the natural endocannabinoid level in the body. If you’re lucky enough to have this mutation, you’ll feel less anxious than a normal person but conversely, since you have extra cannabinoids already, CBD may prove ineffective. Incidentally, you can use a service such as 23andMe to predict how you’ll respond to weed.


If you’re a female, you’re naturally more sensitive to the cannabinoids in weed – including CBD. This means you are also more likely to benefit from pain relief. Also, as men are generally larger than women, they need higher doses of CBD than women to alleviate chronic pain.

The menstrual cycle also has a significant effect on how marijuana works. Research shows that THC works closely with estrogen, so weed is most powerful in women when estrogen levels are at their peak. It is unclear if CBD is more effective during the period.

Biochemistry & Lifestyle

Even ignoring gene mutations and biological sex, we’re all wired differently which means some people are simply more sensitive to CBD than others. For example, do you notice how you can have six beers and feel okay while your friend is on the floor after two? It is all about the ECS yet again. Factors such as genetics, stress, diet, and lifestyle impact how the ECS functions.

If CBD isn’t working for you, take a close look at your lifestyle, and pay particular attention to the amount of fatty acids in your diet. If your diet is low in fatty acids, especially omega-3, your ECS will not function at a high level. CBD is a form of fatty acid so if you’re already consuming a lot, cannabidiol will not be as effective as in someone who is lacking in fatty acids. Also, if your CB2 receptors are stronger than the CB1 receptors, or vice versa, CBD will not be as effective because your biochemistry affects your endocannabinoid balance.

Physical Health

By now, it should be apparent that CBD works best in people with significant endocannabinoid gaps. If you’re in excellent shape with no real ailments, CBD oil won’t help you as much as if you had a condition such as fibromyalgia. Individuals with medical conditions have altered biochemistry and when you consume CBD, it produces a number of chemical interactions in the body which work to restore internal homeostasis.

If you have fibromyalgia for example, your body is in dire need of cannabinoidsת so CBD should help reduce chronic pain and perhaps give you an energy boost.

Psychological Health

Once again, CBD will be far more effective if you suffer from anxiety, depression, PTSD or another issue that is affecting your mental health. In this instance, there is a chemical imbalance in the brain and is partially to blame for your mental issues. When you use CBD, the chemical balance could be restored which should make you feel a whole lot better.


Generally speaking, the more CBD you use, the greater your tolerance. It stands to reason that if you’ve used 100mg a day for five years, then it won’t have the same effect as when using it for the first time. Fortunately, there are ways to address the situation. One of the best methods of decreasing tolerance is to take a CBD break. Even a couple of weeks should be enough to restore disorder and ensure your body reacts positively to the ‘new’ stimuli.

Strains & The Entourage Effect

There are hundreds of marijuana strains and practically none of them have identical levels of THC, CBD or other cannabinoids. The best CBD strains include Harlequin, Charlotte’s Web, Cannatonic, and Canna-Tsu. While Charlotte’s Web has enormous amounts of CBD but minimal THC, Harlequin has more than enough THC to get you stoned.

Then there is the small matter of the entourage effect, which essentially means that CBD oil works best when it contains other natural “full-spectrum” cannabis compounds like terpenes and flavonoids. Based on several studies, CBD is not particularly effective when taken by itself as an isolate.

The most effective products combine dozens of cannabinoids, although if you live in one of the 21 states where weed is illegal, you won’t be able to use a strain that contains THC. Even so, there is plenty of good CBD oil which includes terpenes and other goodies.

Final Thoughts on CBD Oil’s Efficacy

If CBD oil doesn’t work for you, it’s a terrible shame because it is a wonderful all-natural medicine and a fantastic alternative to addictive and dangerous pharmaceuticals. If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Go through the list and see if anything applies to your situation. Perhaps you’ve purchased bad oil? Maybe your genetics or biochemistry means cannabinoids don’t work. Or, perhaps you’re simply not taking a strong enough dose.