Why CBD Oil Won’t Work for Everyone [Answered]

Explaining in detail
MarijuanaBreak Staff / Updated on March 26, 2018

Why CBD Oil Won’t Work for Everyone [Answered]

Here’s the thing about CBD oil; while it works wonderfully for hundreds of thousands of people, it is NOT a miracle cure. A growing body of CBD research shows its capability in relation to easing the symptoms of conditions such as social anxiety diseases, insomnia, fibromyalgia, cancer, and many others.

However, we believe in CBD oil, NOT snake oil, which is why we know it is not 100% effective for everyone; nothing is. That’s why we get angry when people suggest CBD oil is a scam because it didn’t work for THEM. What you have to realize is that there are good reasons why CBD oil didn’t work for you — and it has nothing to do with its efficacy as a whole. Let’s go into further detail and explore some reasons why CBD isn’t working for you.

Brand & Dosage

Let’s start with the basics: Perhaps you have bought a bad product or else you’re not using enough. Never purchase CBD oil from a company that doesn’t also offer third-party lab results. At present, it is an unregulated industry so a lot of low-standard oil gets through. Third party testing from a reputable lab removes most of the doubt about the reputation of the brand.

In some cases, you’ll get companies that claim their bottles have 1,000mg of CBD but only have 200mg or less. Without lab results, how can you tell? Also, if you are using a quality brand, are you taking enough? And are you using it every day? Generic dosage recommendations are doing the rounds. Here are some examples:

  • 2.5mg a day to increase appetite in cancer patients.
  • 2.5 – 20mg daily to alleviate chronic pain.
  • Up to 400mg a day for epilepsy.

Notice the different doses per condition and the large range? Always begin with a low dose, but keep increasing it until you feel an effect. If you go as far as 100mg a day for pain for instance, and it isn’t working, perhaps CBD is not for you.


Unfortunately, your genetics could be to blame. The reason why CBD oil works is due to the way the body interacts with it. If you have a genetic anxiety disorder for example, you could experience paranoia when using THC but CBD should help you. CBD works with the endocannabinoid system (ECS) and believe it or not, some of us are born with more endocannabinoids than others.

For the record, around 20% of Americans have a genetic mutation that increases the natural endocannabinoid level in the body. If you’re lucky enough to have this mutation, you’ll feel less anxious than a normal person but conversely, since you have extra cannabinoids already, CBD may prove ineffective. Incidentally, you can use a service such as 23andMe to predict how you’ll respond to weed.


If you’re a female, you’re naturally more sensitive to the cannabinoids in weed – including CBD. This means you are also more likely to benefit from pain relief. Also, as men are generally larger than women, they need higher doses of CBD than women to alleviate chronic pain.

The menstrual cycle also has a significant effect on how marijuana works. Research shows that THC works closely with estrogen, so weed is most powerful in women when estrogen levels are at their peak. It is unclear if CBD is more effective during the period.

Biochemistry & Lifestyle

Even ignoring gene mutations and biological sex, we’re all wired differently which means some people are simply more sensitive to CBD than others. For example, do you notice how you can have six beers and feel okay while your friend is on the floor after two? It is all about the ECS yet again. Factors such as genetics, stress, diet, and lifestyle impact how the ECS functions.

If CBD isn’t working for you, take a close look at your lifestyle, and pay particular attention to the amount of fatty acids in your diet. If your diet is low in fatty acids, especially omega-3, your ECS will not function at a high level. CBD is a form of fatty acid so if you’re already consuming a lot, cannabidiol will not be as effective as in someone who is lacking in fatty acids. Also, if your CB2 receptors are stronger than the CB1 receptors, or vice versa, CBD will not be as effective because your biochemistry affects your endocannabinoid balance.

Physical Health

By now, it should be apparent that CBD works best in people with significant endocannabinoid gaps. If you’re in excellent shape with no real ailments, CBD oil won’t help you as much as if you had a condition such as fibromyalgia. Individuals with medical conditions have altered biochemistry and when you consume CBD, it produces a number of chemical interactions in the body which work to restore internal homeostasis.

If you have fibromyalgia for example, your body is in dire need of cannabinoidsת so CBD should help reduce chronic pain and perhaps give you an energy boost.

Psychological Health

Once again, CBD will be far more effective if you suffer from anxiety, depression, PTSD or another issue that is affecting your mental health. In this instance, there is a chemical imbalance in the brain and is partially to blame for your mental issues. When you use CBD, the chemical balance could be restored which should make you feel a whole lot better.


Generally speaking, the more CBD you use, the greater your tolerance. It stands to reason that if you’ve used 100mg a day for five years, then it won’t have the same effect as when using it for the first time. Fortunately, there are ways to address the situation. One of the best methods of decreasing tolerance is to take a CBD break. Even a couple of weeks should be enough to restore disorder and ensure your body reacts positively to the ‘new’ stimuli.

Strains & The Entourage Effect

There are hundreds of marijuana strains and practically none of them have identical levels of THC, CBD or other cannabinoids. The best CBD strains include Harlequin, Charlotte’s Web, Cannatonic, and Canna-Tsu. While Charlotte’s Web has enormous amounts of CBD but minimal THC, Harlequin has more than enough THC to get you stoned.

Then there is the small matter of the entourage effect, which essentially means that CBD oil works best when it contains other natural “full-spectrum” cannabis compounds like terpenes and flavonoids. Based on several studies, CBD is not particularly effective when taken by itself as an isolate.

The most effective products combine dozens of cannabinoids, although if you live in one of the 21 states where weed is illegal, you won’t be able to use a strain that contains THC. Even so, there is plenty of good CBD oil which includes terpenes and other goodies.

Final Thoughts on CBD Oil’s Efficacy

If CBD oil doesn’t work for you, it’s a terrible shame because it is a wonderful all-natural medicine and a fantastic alternative to addictive and dangerous pharmaceuticals. If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Go through the list and see if anything applies to your situation. Perhaps you’ve purchased bad oil? Maybe your genetics or biochemistry means cannabinoids don’t work. Or, perhaps you’re simply not taking a strong enough dose.

Why CBD Oil Won’t Work for Everyone [Answered]
March 26, 2018
4.8 16
  1. Dan Scariato

    I tried it with a sample (a few drops under my tongue) from the store & I was very excited to finally get some help with insomnia & inflammation & other “miracle cures” from CBD. I talked to the lady behind the counter for over 30 minutes because it was slow in the store & I started feeling weird. The same way I feel when I smoke pot. I got angry & confused & very anxious for 2 days it lasted. It was so bad that I got in an argument with a friend & I almost attacked him & could see myself with my fist beating the hell out of him. I went in my house & waited for the evil crap to get out of my system. I am not making this up, I live in Colorado & I am 62 years old. I have since talked to other people that had a similar results but are afraid to tell anyone. I think pot & cbd is bad stuff & I must admit that some of my friends swear by it, I do not. I have a bottle I paid 75.00 for & gave it to a family member. My advice is stay away from it, waste of money, snake oil at best!

  2. Calikoat
    No Effect

    I tried 50 mg a day without any effect….would try higher doses but it is just too expensive

  3. Chauncey

    I’ve tried vaping, oil, tincture, flower, and topicals for my fibromyalgia pain. Other than fibromyalgia, I’m healthy – I don’t consume sugar or alcohol, etc. I don’t take RX at all. This stuff does absolutely nothing (not entirely true as flower made me nauseous for days) and it doesn’t seem to help anyone else I’ve talked to about it. Placebo at best, and way too expensive to continue to try to figure it out.

  4. Wisdom

    I tried the pure kana 1000mg cbd oil , and it did absolutely nothing for me. Felt no different, no improvement in anything, just a placebo in my opinion.

  5. Susanna

    Have you heard of Bodē Wellness? It’s out of Colorado.

  6. Maggie

    It hasn’t worked for me. I have tried it over a 5-week period. Took 5 drops a day in the beginning, seemed to decrease the swelling in my feet for about a week, then things started to go downhill. I didn’t make any other changes as far as food, activity, beverages, etc. I had terrible bathroom issues. So, I stopped the CBD as well as the supplement I had been taking prior to the CBD. Waited 5 days, then added back the supplement, everything was fine. Stopped the supplement for 5 days, added back the CBD oil (to rule out interaction between the two.) The CBD oil wrecks my GI tract – I can’t spend hours in the bathroom every day, so I realize it is not for me. I purchased the KANA oil which is supposed to be primo – so it obviously is me, not the oil. We are not a match.

  7. Amber

    Yeah…I’m one where it doesn’t work. I’ve tried vaping. Failed. CBD oil. Suggested i do 30mg a day. I did half that and it burned a hole in my stomach. Every time I burped i tasted blood. I tried smoking pot 3 times in my life. First time i ended up in hospital because i wasn’t able to lower my blood sugars while I was high. My insulin had no effect. 2nd time made me paranoid so bad i crawled under the bed and cried for hours. 3rd and final time i felt so dead i cut myself with a razor. I suffer from chronic pain. I don’t want hard RX drugs, but looks like the RXs stuff I’ll need. Every single person i know–family friends— loves it. I’ll just stay away from it. I’m healthy eater. Rarely eat junk food. Love fruits and veggies. That’s 90 percent of what i eat in a day. Weird, huh?

  8. Megan

    I just tried an oil that works great for my parents. Ive felt very lethargic and sick all day since I took it. I feel like I’m sick. Should I try another brand?

    1. Adam

      Every person is individual. What works for one may not work for another. Obviously if you feel sick do not continue.

  9. Sylvia

    Elixinol CBD oil capsules taken 4 at a time did nothing for my anxiety or insomnia. Did nothing at all in fact. Don’t waste your time on the stuff without THC. No matter what anyone tells you, without the THC, its worthless.

  10. OrganisedPauper

    I tried CBD to see if it would help with fibromyalgia, sleep maintenance insomnia and Bipolar. It made me really ill. After only 2 days I had a massive upswing in pain, followed by a 2 day migraine. Alsoa big increase in insomnia which is still ongoing 5 days after stopping. None of this was anywhere near a normal fluctuation of my condition. The same CBD oil has worked really well for my husband and improved his sleep quality.

    I suspect my genetics have something to do with the bad reaction as I have had really quite odd, and negative, reactions to some prescription meds as well as some alternative meds/herbs. Yet other ones that are known to be problematic I’ve had no problems with.

    1. Roxanne

      The CBD oil was removing toxins from your body. I went through the same flu like symptoms. It got better after about a week or two and now its great! Its normal to have that happen as it detoxifies your cells.

  11. niella

    Hello. Have you heard of Bluebird Botanicals? I’m currently using their CBD oil, and I haven’t seen much change in my anxiety so far.

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