Why CBD Oil Won’t Work for Everyone [Answered]
March 26, 2018

Why CBD Oil Won’t Work for Everyone [Answered]

Explaining in detail
MarijuanaBreak Staff MarijuanaBreak Staff / Updated on March 26, 2018

Why CBD Oil Won’t Work for Everyone [Answered]

Here’s the thing about CBD oil; while it works wonderfully for hundreds of thousands of people, it is NOT a miracle cure. A growing body of CBD research shows its capability in relation to easing the symptoms of conditions such as social anxiety diseases, insomnia, fibromyalgia, cancer, and many others.

However, we believe in CBD oil, NOT snake oil, which is why we know it is not 100% effective for everyone; nothing is. That’s why we get angry when people suggest CBD oil is a scam because it didn’t work for THEM. What you have to realize is that there are good reasons why CBD oil didn’t work for you — and it has nothing to do with its efficacy as a whole. Let’s go into further detail and explore some reasons why CBD isn’t working for you.

Brand & Dosage

Let’s start with the basics: Perhaps you have bought a bad product or else you’re not using enough. Never purchase CBD oil from a company that doesn’t also offer third-party lab results. At present, it is an unregulated industry so a lot of low-standard oil gets through. Third party testing from a reputable lab removes most of the doubt about the reputation of the brand.

In some cases, you’ll get companies that claim their bottles have 1,000mg of CBD but only have 200mg or less. Without lab results, how can you tell? Also, if you are using a quality brand, are you taking enough? And are you using it every day? Generic dosage recommendations are doing the rounds. Here are some examples:

  • 2.5mg a day to increase appetite in cancer patients.
  • 2.5 – 20mg daily to alleviate chronic pain.
  • Up to 400mg a day for epilepsy.

Notice the different doses per condition and the large range? Always begin with a low dose, but keep increasing it until you feel an effect. If you go as far as 100mg a day for pain for instance, and it isn’t working, perhaps CBD is not for you.


Unfortunately, your genetics could be to blame. The reason why CBD oil works is due to the way the body interacts with it. If you have a genetic anxiety disorder for example, you could experience paranoia when using THC but CBD should help you. CBD works with the endocannabinoid system (ECS) and believe it or not, some of us are born with more endocannabinoids than others.

For the record, around 20% of Americans have a genetic mutation that increases the natural endocannabinoid level in the body. If you’re lucky enough to have this mutation, you’ll feel less anxious than a normal person but conversely, since you have extra cannabinoids already, CBD may prove ineffective. Incidentally, you can use a service such as 23andMe to predict how you’ll respond to weed.


If you’re a female, you’re naturally more sensitive to the cannabinoids in weed – including CBD. This means you are also more likely to benefit from pain relief. Also, as men are generally larger than women, they need higher doses of CBD than women to alleviate chronic pain.

The menstrual cycle also has a significant effect on how marijuana works. Research shows that THC works closely with estrogen, so weed is most powerful in women when estrogen levels are at their peak. It is unclear if CBD is more effective during the period.

Biochemistry & Lifestyle

Even ignoring gene mutations and biological sex, we’re all wired differently which means some people are simply more sensitive to CBD than others. For example, do you notice how you can have six beers and feel okay while your friend is on the floor after two? It is all about the ECS yet again. Factors such as genetics, stress, diet, and lifestyle impact how the ECS functions.

If CBD isn’t working for you, take a close look at your lifestyle, and pay particular attention to the amount of fatty acids in your diet. If your diet is low in fatty acids, especially omega-3, your ECS will not function at a high level. CBD is a form of fatty acid so if you’re already consuming a lot, cannabidiol will not be as effective as in someone who is lacking in fatty acids. Also, if your CB2 receptors are stronger than the CB1 receptors, or vice versa, CBD will not be as effective because your biochemistry affects your endocannabinoid balance.

Physical Health

By now, it should be apparent that CBD works best in people with significant endocannabinoid gaps. If you’re in excellent shape with no real ailments, CBD oil won’t help you as much as if you had a condition such as fibromyalgia. Individuals with medical conditions have altered biochemistry and when you consume CBD, it produces a number of chemical interactions in the body which work to restore internal homeostasis.

If you have fibromyalgia for example, your body is in dire need of cannabinoidsת so CBD should help reduce chronic pain and perhaps give you an energy boost.

Psychological Health

Once again, CBD will be far more effective if you suffer from anxiety, depression, PTSD or another issue that is affecting your mental health. In this instance, there is a chemical imbalance in the brain and is partially to blame for your mental issues. When you use CBD, the chemical balance could be restored which should make you feel a whole lot better.


Generally speaking, the more CBD you use, the greater your tolerance. It stands to reason that if you’ve used 100mg a day for five years, then it won’t have the same effect as when using it for the first time. Fortunately, there are ways to address the situation. One of the best methods of decreasing tolerance is to take a CBD break. Even a couple of weeks should be enough to restore disorder and ensure your body reacts positively to the ‘new’ stimuli.

Strains & The Entourage Effect

There are hundreds of marijuana strains and practically none of them have identical levels of THC, CBD or other cannabinoids. The best CBD strains include Harlequin, Charlotte’s Web, Cannatonic, and Canna-Tsu. While Charlotte’s Web has enormous amounts of CBD but minimal THC, Harlequin has more than enough THC to get you stoned.

Then there is the small matter of the entourage effect, which essentially means that CBD oil works best when it contains other natural “full-spectrum” cannabis compounds like terpenes and flavonoids. Based on several studies, CBD is not particularly effective when taken by itself as an isolate.

The most effective products combine dozens of cannabinoids, although if you live in one of the 21 states where weed is illegal, you won’t be able to use a strain that contains THC. Even so, there is plenty of good CBD oil which includes terpenes and other goodies.

Final Thoughts on CBD Oil’s Efficacy

If CBD oil doesn’t work for you, it’s a terrible shame because it is a wonderful all-natural medicine and a fantastic alternative to addictive and dangerous pharmaceuticals. If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Go through the list and see if anything applies to your situation. Perhaps you’ve purchased bad oil? Maybe your genetics or biochemistry means cannabinoids don’t work. Or, perhaps you’re simply not taking a strong enough dose.

  1. Shani
    CBD for Anxiety

    CBD oil made my heart pound. I suffer with anxiety & was hoping CBD would help calm my heart palpitations but it made it worst. Since none of these are regulated maybe the brand I purchased was bad. I will try Charlottes Web next.

  2. Kate
    Makes things worse for me!

    I don’t know about anyone else but so far cbd oil is actually making my insomnia worse!
    I’ve been taking it for about 3 weeks now and for the first few nights, it seemed to have a very small relaxation effect and I even managed to sleep a bit … however, now I think my tolerance has built up and it’s actually making me feel really bad.
    I immediately get a headache and after a few minutes my joints feel as though they are on fire! My heart beats faster and heavier and I feel more anxious than ever. Needless to say … no sleep !
    I bought a high quality oil and am now feeling a bit disappointed that once again my insomnia goes untreated … I was really hoping for some help here.

    1. Donavon Jackson
      Dosage and timing!

      Regardless of brand. First thought here is to reduce the dose. cut it in half at the very least. Second thought here is to not take it right before bedtime. If it is a Full Spectrum product it contains hundreds of other compounds that may actually be the cause of the poor reaction. Cut the dose and take it much earlier in the evening…at least 3-4 hours earlier than bedtime.

  3. Cloud
    Unlucky soul

    I’ve lived with Chronic back pain for over 40 yrs, I tried CBD oil and I can’t tell it has decreased the pain, it does about as much good for me as Tramadol did which wasn’t a lot for severe constant pain, I take 500 mg. And I can’t take it afternoons or nights as instead of making me sleepy , I get wired (as does any prescript that says it will knock you out , those wire me as well ) and it also doesn’t do squat for Neuropathy. For those that it works great , I’m glad, I’m just one those odd balls it doesn’t touch the pain. I thought I was saving husband some money but not really.

  4. Cyndi

    In two weeks the oral drops have erased my 20 years of SI joint pain that narcotics, injections, PT and acupuncture did little to nothing for. I’m amazed to say the least. The oral drops did nothing for my chronic foot pain which is more of a bone-on-bone problem so I started using CBD salve twice a day and am now close to a “0” for foot pain- even going up stairs, etc. Mind blown again!! I feel incredibly grateful that it works for me. Wish it woreked for everyone….

  5. Viv
    Newbie disappointed and regretting use

    Just tried it sublingually and even spit out as much as i could after about 40 seconds. Terrible experience. Pretty much immediately got a headache (sudden sharp pain) and tinnitus. Also burned my mouth and tongue and they are still burning. Ditto the esophagus for tiny bit that got down. I am like the poster tho who said reacts badly and oddly to big pharma meds too. I thought the brand i was getting was good source. Green roads. Ingredients. Cbd oil (7.5 mg per 1 ml – lowest dosage they have), hemp seed oil, glycerine. I took half a ml only. Maybe too much glycerine (i do poorly with sugar alcohol) and i woukd have been better off with higher dose so that i could just have put one or two drops in my mouth like others posted. Not sure what to do now. Wanted it to deceease neuropathy and inflammation and hyperandrenergic state of unknown cause. Dissapointed. Hope i didnt poison myself. Still burning…eye burning too- most odd. Forgot i was planning to vaporize it instead of putting in my mouth. Shoujd i try or woukd tgat be ill advised given response.

  6. Jen
    Not sure if I'm one of the "lucky" ones it doesn't work for

    I began using cbd oil mid Oct for pain in my legs and back. I researched everything I could about it, along with the ECS, so I know to take it a few times a day, every day, to keep it in your system. I know to use it for 30-60 days, and I hold it under my tongue for a min. 3 bottles later, 500, 1000 and now 2500, I feel worse actually. I read to use a different brand, but that’s confusing, how could there be anything that’d be different than what I’m taking? I bought it from a reputable oil shop who does the research for customers and I trust them since they are the only one and they believe very strongly in CBD. So many others feel immediate relief, but not me. It REALLY bums me out, I had such high hopes. When I jumped from the 1000 to the 2500, I had concerns so started at the 1/4 and am now 1 to 1 1/2 ml a day, which is a lot of oil, with zero results.

    1. Charmaine Kavanagh
      Not effective and no reason why!

      OMG Me too! I have 40+ years of increasing DDD and Spinal Stenosis. Pain meds/therapies DO NOT relieve pain. I tried different brands and referred to dosages I read online. I bought my last bottle 2 weeks ago – 1000mg Full Spectrum CBD OIL. Each “Dropper” is 1ml of 32mg CBD. I gradually increased from 1 single drop to full droppers. I was up to what the bottle says – 1 DROPPER (not drop) every 3-4 hour – I was not getting ANY relief and became paranoid/anxious, pain actually feels worse. I decided to just finish the expensive bottle by taking every 1-2 hours – FULL DROPPER …. Sad to report – same pain and at times worse.

  7. Dan Scariato

    I tried it with a sample (a few drops under my tongue) from the store & I was very excited to finally get some help with insomnia & inflammation & other “miracle cures” from CBD. I talked to the lady behind the counter for over 30 minutes because it was slow in the store & I started feeling weird. The same way I feel when I smoke pot. I got angry & confused & very anxious for 2 days it lasted. It was so bad that I got in an argument with a friend & I almost attacked him & could see myself with my fist beating the hell out of him. I went in my house & waited for the evil crap to get out of my system. I am not making this up, I live in Colorado & I am 62 years old. I have since talked to other people that had a similar results but are afraid to tell anyone. I think pot & cbd is bad stuff & I must admit that some of my friends swear by it, I do not. I have a bottle I paid 75.00 for & gave it to a family member. My advice is stay away from it, waste of money, snake oil at best!

    1. Henry
      CDB Doesn't work

      True statement CBD OIL. Not good n waste of money UNREAL REACTION I HAD N NOTHING to help the pain

  8. Calikoat
    No Effect

    I tried 50 mg a day without any effect….would try higher doses but it is just too expensive

  9. Chauncey

    I’ve tried vaping, oil, tincture, flower, and topicals for my fibromyalgia pain. Other than fibromyalgia, I’m healthy – I don’t consume sugar or alcohol, etc. I don’t take RX at all. This stuff does absolutely nothing (not entirely true as flower made me nauseous for days) and it doesn’t seem to help anyone else I’ve talked to about it. Placebo at best, and way too expensive to continue to try to figure it out.

    1. Terry Walker
      I finally found the perfect source of pure CBD

      Hello, I’m glad I came across this. Here’s my take on CBD and how it has helped me and others that I know. So, first let me start off by saying that I tried CBD for the first time from this tobacco shop near by house which was watered down and didn’t have real CBD in it because I didn’t feel a thing. But of course I never gave up my search in finding some good CBD and I knew that it would benefit me. So, with my search I came across this amazing company with some incredible CBD and also non CBD products but still offer tremendous benefits. I feel in love with their products and I’m currently sharing it with everyone I know.
      For those of you who are still on a mission to find some really good and pure CBD Oil, represented by our 3rd party company who also provides Lab results on all of our products , please get in contact with me. I would rather try to help someone that needs this stuff then to sit back and hope that they find what they are looking for when I know where to point them to.

      1. Paula Graham
        Please help!

        Thank you for your article…would you mind telling me where I can get the truly good cbd oil for my sleep problems.
        I am trying some now and for a few days it worked but I seem to already be used to it and the calming effect seems to have been lost.
        This was oil bought over the counter..so would like to try a truly good one.
        Thank you

  10. Wisdom

    I tried the pure kana 1000mg cbd oil , and it did absolutely nothing for me. Felt no different, no improvement in anything, just a placebo in my opinion.

  11. Susanna

    Have you heard of Bodē Wellness? It’s out of Colorado.

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