Why CBD Oil Won’t Work for Everyone [Answered]

Explaining in detail
MarijuanaBreak Staff MarijuanaBreak Staff / Updated on June 9, 2019

Why CBD Oil Won’t Work for Everyone [Answered]

Here’s the thing about CBD oil; while it works wonderfully for hundreds of thousands of people, it is NOT a miracle cure. A growing body of CBD research shows its capability in relation to easing the symptoms of conditions such as social anxiety diseases, insomnia, fibromyalgia, cancer, and many others.

However, we believe in CBD oil, NOT snake oil, which is why we know it is not 100% effective for everyone; nothing is. That’s why we get angry when people suggest CBD oil is a scam because it didn’t work for THEM. What you have to realize is that there are good reasons why CBD oil didn’t work for you — and it has nothing to do with its efficacy as a whole. Let’s go into further detail and explore some reasons why CBD isn’t working for you.

Brand & Dosage

Let’s start with the basics: Perhaps you have bought a bad product or else you’re not using enough. Never purchase CBD oil from a company that doesn’t also offer third-party lab results. At present, it is an unregulated industry so a lot of low-standard oil gets through. Third party testing from a reputable lab removes most of the doubt about the reputation of the brand.

In some cases, you’ll get companies that claim their bottles have 1,000mg of CBD but only have 200mg or less. Without lab results, how can you tell? Also, if you are using a quality brand, are you taking enough? And are you using it every day? Generic dosage recommendations are doing the rounds. Here are some examples:

  • 2.5mg a day to increase appetite in cancer patients.
  • 2.5 – 20mg daily to alleviate chronic pain.
  • Up to 400mg a day for epilepsy.

Notice the different doses per condition and the large range? Always begin with a low dose, but keep increasing it until you feel an effect. If you go as far as 100mg a day for pain for instance, and it isn’t working, perhaps CBD is not for you.


Unfortunately, your genetics could be to blame. The reason why CBD oil works is due to the way the body interacts with it. If you have a genetic anxiety disorder for example, you could experience paranoia when using THC but CBD should help you. CBD works with the endocannabinoid system (ECS) and believe it or not, some of us are born with more endocannabinoids than others.

For the record, around 20% of Americans have a genetic mutation that increases the natural endocannabinoid level in the body. If you’re lucky enough to have this mutation, you’ll feel less anxious than a normal person but conversely, since you have extra cannabinoids already, CBD may prove ineffective. Incidentally, you can use a service such as 23andMe to predict how you’ll respond to weed.


If you’re a female, you’re naturally more sensitive to the cannabinoids in weed – including CBD. This means you are also more likely to benefit from pain relief. Also, as men are generally larger than women, they need higher doses of CBD than women to alleviate chronic pain.

The menstrual cycle also has a significant effect on how marijuana works. Research shows that THC works closely with estrogen, so weed is most powerful in women when estrogen levels are at their peak. It is unclear if CBD is more effective during the period.

Biochemistry & Lifestyle

Even ignoring gene mutations and biological sex, we’re all wired differently which means some people are simply more sensitive to CBD than others. For example, do you notice how you can have six beers and feel okay while your friend is on the floor after two? It is all about the ECS yet again. Factors such as genetics, stress, diet, and lifestyle impact how the ECS functions.

If CBD isn’t working for you, take a close look at your lifestyle, and pay particular attention to the amount of fatty acids in your diet. If your diet is low in fatty acids, especially omega-3, your ECS will not function at a high level. CBD is a form of fatty acid so if you’re already consuming a lot, cannabidiol will not be as effective as in someone who is lacking in fatty acids. Also, if your CB2 receptors are stronger than the CB1 receptors, or vice versa, CBD will not be as effective because your biochemistry affects your endocannabinoid balance.

Physical Health

By now, it should be apparent that CBD works best in people with significant endocannabinoid gaps. If you’re in excellent shape with no real ailments, CBD oil won’t help you as much as if you had a condition such as fibromyalgia. Individuals with medical conditions have altered biochemistry and when you consume CBD, it produces a number of chemical interactions in the body which work to restore internal homeostasis.

If you have fibromyalgia for example, your body is in dire need of cannabinoidsת so CBD should help reduce chronic pain and perhaps give you an energy boost.

Psychological Health

Once again, CBD will be far more effective if you suffer from anxiety, depression, PTSD or another issue that is affecting your mental health. In this instance, there is a chemical imbalance in the brain and is partially to blame for your mental issues. When you use CBD, the chemical balance could be restored which should make you feel a whole lot better.


Generally speaking, the more CBD you use, the greater your tolerance. It stands to reason that if you’ve used 100mg a day for five years, then it won’t have the same effect as when using it for the first time. Fortunately, there are ways to address the situation. One of the best methods of decreasing tolerance is to take a CBD break. Even a couple of weeks should be enough to restore disorder and ensure your body reacts positively to the ‘new’ stimuli.

Strains & The Entourage Effect

There are hundreds of marijuana strains and practically none of them have identical levels of THC, CBD or other cannabinoids. The best CBD strains include Harlequin, Charlotte’s Web, Cannatonic, and Canna-Tsu. While Charlotte’s Web has enormous amounts of CBD but minimal THC, Harlequin has more than enough THC to get you stoned.

Then there is the small matter of the entourage effect, which essentially means that CBD oil works best when it contains other natural “full-spectrum” cannabis compounds like terpenes and flavonoids. Based on several studies, CBD is not particularly effective when taken by itself as an isolate.

The most effective products combine dozens of cannabinoids, although if you live in one of the 21 states where weed is illegal, you won’t be able to use a strain that contains THC. Even so, there is plenty of good CBD oil which includes terpenes and other goodies.

Final Thoughts on CBD Oil’s Efficacy

If CBD oil doesn’t work for you, it’s a terrible shame because it is a wonderful all-natural medicine and a fantastic alternative to addictive and dangerous pharmaceuticals. If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Go through the list and see if anything applies to your situation. Perhaps you’ve purchased bad oil? Maybe your genetics or biochemistry means cannabinoids don’t work. Or, perhaps you’re simply not taking a strong enough dose.

  1. Patti
    1 hit wonder

    The first time I used CBD oil it was wonderful. I have End stage osteoarthritis in my left hip and in severe chronic agonizing pain 24/7. I am waiting to at a hip replacement but I have about 50 more pounds to lose. It took away the inflammation and I could walk without pain!!! I still had to use my walker because I basically have no hip joint left but it was amazing! The next day and since though, NOTHING. I cried and cried. It was like all hope had been snatched away. I took half a ml and the brand was SUNMED. Anyone else have similar results and have any suggestions?

  2. John Buckner
    Change the brand

    I think CBD oil works for all, but yes, sometimes the effect is so negligible, that it can be considered zero. For such patients, I would say first try to change the brand of your CBD, it works in 90% of the cases, and if still it does not, then better go for cannabis or something else.

  3. Belva Gonda

    Soo sorry for all you poor people that dont get to experience the wonderful relief of CBD!.
    Stage 4 breast cancer the past 6yrs, anxiety- depression- PTSD & insomnia for over 25yrs, chronic arthritis and joint pain caused by chemotherapy treatment.
    I have been on every medication with a million horrible side effects.
    FINALLY- NO PAIN! I GO TO SLEEP AND SLEEP WELL, NO DEPRESSION, NO ANXIETY! and all the horrible side effects are gone. Everyday I feel like a newer and better person and get excited for the next day to see how much happier I can be! Everyone is amazed. My husband is taking Vicodin for a bad injury from a motorcycle wreck- hes a carpenter and torn his shoulder open. He was taking 8 a day with constant pain. He started taking cbd one month ago- he realized last night that its helped so much with pain, hes only taking 3 Vicodin pills a day now. Feels happier and sleeps better. Its definately NOT A PLACEBO- watch the videos of people with epilepsy getting dosed while in a fit- A PLACEBO DOES NOT ACTUALLY WORK- CBD DOES!.
    I feel really sorry for the people it doesnt work for because its SO much more affordable then pharmaceuticals, with NO bad side effects! ✌

  4. Sheila
    Nothing Happening

    Inphynite 500 mg/ml began with 2 drops sublingually increased to 15 and nothing. Just…..nothing. I feel like I paid 90 bucks for salad oil. This stuff is green and rich. This has to be something to do with genetics. Im going to start 1/4 pipettes to 1/2 pipettes to see if it helps. At this point I’m ready to go back to narcos.

  5. Pam Jaeger
    did not notice much effect at all.

    I have tried an isolate, and two different brands of cbd oil. I really wanted to feel SOMETHING but I noticed nothing really. I have mild sciatica and not sure whether it even helps with that. if it does it is no better than motrin. I bought some for my grandson who has anxiety issues and focusing and it seemed like it helped him. but the effect is so minimal it is not worth the money! as for taking more, well how much more do you need to take and my gosh it is so expensive. most people just can’t spend 200 a month on this. I predict the pharmaceutical companies will start entering the market quickly with their own version of cbd which can be purchased with prescription. that will bring the price down and shove most of the scammer cbd oil companies out of business. If it works for you, great, but I have to pass.

  6. Adam Hefner
    Mind Is Strong

    Placebo is strong. Seriously. Not even making a slight at cbd or cbda.

    Same goes with basic supplements

  7. Steve George
    No effect at all.

    Sent an email to the company in Colorado asking if I was the only person in America that felt no benefit. They responded by asking what dose I was taking. I responded 30 drops. Have not had a reply since. Helpful when you don’t have an answer of any kind.

  8. Cicelia Moody
    Very well written!

    Very True, bear this in mind. CBD oil works for a lot of people, but it is not necessary that it will work for you. Actualyl it depends upon a number of conditions, like the brand you are using, your own body chemistry, your own body response, you stage of the disease, the formation like the oil or wax or tincture and n number of factors. My son is actually allergic to CBD, he gets severe diarrhea even if he passes a lightly diffused area with CBD oil!

  9. Shani
    CBD for Anxiety

    CBD oil made my heart pound. I suffer with anxiety & was hoping CBD would help calm my heart palpitations but it made it worst. Since none of these are regulated maybe the brand I purchased was bad. I will try Charlottes Web next.

    1. Novella Maia
      Biochemistry and genetic mutations

      I’m 79 yrs old, and rarely used alcohol, never used drugs, and am sensitive to cannabis effects. Have used about 2.5 mg. during the night because of severe insomnia problems. Recently, used my Ancestry DNA info to get an analysis re: genetic mutations and how best to use nutrition in addressing them. This includes things to take, and things to avoid. I need to avoid cannabis–I have genetic anxiety disorder–as did my mother, and as do all four of my children. We can’t adequately emphasize the importance of remembering “biochemical individuality”!!

  10. Kate
    Makes things worse for me!

    I don’t know about anyone else but so far cbd oil is actually making my insomnia worse!
    I’ve been taking it for about 3 weeks now and for the first few nights, it seemed to have a very small relaxation effect and I even managed to sleep a bit … however, now I think my tolerance has built up and it’s actually making me feel really bad.
    I immediately get a headache and after a few minutes my joints feel as though they are on fire! My heart beats faster and heavier and I feel more anxious than ever. Needless to say … no sleep !
    I bought a high quality oil and am now feeling a bit disappointed that once again my insomnia goes untreated … I was really hoping for some help here.

    1. Donavon Jackson
      Dosage and timing!

      Regardless of brand. First thought here is to reduce the dose. cut it in half at the very least. Second thought here is to not take it right before bedtime. If it is a Full Spectrum product it contains hundreds of other compounds that may actually be the cause of the poor reaction. Cut the dose and take it much earlier in the evening…at least 3-4 hours earlier than bedtime.

  11. Cloud
    Unlucky soul

    I’ve lived with Chronic back pain for over 40 yrs, I tried CBD oil and I can’t tell it has decreased the pain, it does about as much good for me as Tramadol did which wasn’t a lot for severe constant pain, I take 500 mg. And I can’t take it afternoons or nights as instead of making me sleepy , I get wired (as does any prescript that says it will knock you out , those wire me as well ) and it also doesn’t do squat for Neuropathy. For those that it works great , I’m glad, I’m just one those odd balls it doesn’t touch the pain. I thought I was saving husband some money but not really.

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